Sep 01, 2020 · Dendritic cell-derived small extracellular vesicles (DC-sEVs) are proposed as a novel candidate for tumor antigen-based cancer immunotherapy. In order to improve the DC-sEV-induced antitumor immunity, production of DC-sEVs capable of inducing potent antigen-specific humoral and cellular immune responses is necessary.
Dendritic cells get activated by inflammatory processes (i.e. infections) and their MHC class II molecules present epitopes from autoantigens to CD4 + T cells. The primed CD4 + T cells license DC to activate CD8 + T cells by cross-presenting autoantigens, and these then differentiate into regulatory and cytotoxic T cells. Bio X Cell - InVivoMAb anti-mouse CD8The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to class I MHC molecules displayed by antigen presenting cells (APC). CD8 is primarily eed on the surface of cytotoxic T cells, but can also be found on thymocytes, natural killer cells, and some dendritic cell
The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to class I MHC molecules displayed by antigen presenting cells (APC). CD8 is primarily eed on the surface of cytotoxic T cells, but can also be found on thymocytes, natural killer cells, and some dendritic cell CD8A - T-cell surface glycoprotein CD8 alpha chain Jul 21, 1986 · CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be eed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells
Oct 19, 1998 · Activation of autoreactive T cells can lead to autoimmune diseases such as insulin-dependent diabetes mellitus (IDDM). The initiation and maintenance of IDDM by dendritic cells (DC), the most potent professional antigen-presenting cells, were investigated in transgenic mice eing the lymphocytic choriomeningitis virus glycoprotein (LCMV-GP) under the control of the rat insulin Frontiers Dendritic Cells and CD8 T Cell Immunity in Dec 20, 2018 · Dendritic cells (DCs) play a central role in the regulation of the balance between CD8 T cell immunity vs. tolerance to tumor antigens. Cross-priming, a process which DCs activate CD8 T cells by cross-presenting exogenous antigens, plays a critical role in generating anti-tumor CD8 T cell immunity. However, there are compelling evidences now that the tumor microenvironment (TME)
Dec 20, 2018 · Dendritic cells (DCs) play a central role in the regulation of the balance between CD8 T cell immunity vs. tolerance to tumor antigens. Cross-priming, a process which DCs activate CD8 T cells by cross-presenting exogenous antigens, plays a critical role in generating anti-tumor CD8 T cell immunity. However, there are compelling evidences now that the tumor microenvironment (TME) Galectin-9 interacts with PD-1 and TIM-3 to regulate T Feb 05, 2021 · We found that although both CD4 + and CD8 + T cells were sensitive to Gal-9-induced cell death, CD8 + cytotoxic T cells were particularly more so than CD4 + T cells
Glycoprotein 96 can chaperone both MHC class I- and class II-restricted epitopes for in vivo presentation, but selectively primes CD8+ T cell effector function J Immunol . 2004 May 15;172(10):6087-92. doi:10.4049/jimmunol.172.10.6087. Glycoprotein Gp 96 - an overview ScienceDirect TopicsIt was shown nearly a decade ago that the stress-induced protein gp96 isolated from tumor cell lines was able to induce CD8 + T-cell responses against the tumor during in vivo or in vitro priming (Srivastava et al., 1994). This initially puzzling observation has now been shown to be due to transfer of peptides bound to gp96 molecules from the tumor into an APC, where the peptides can enter the class I pathway.
Apr 21, 2003 · Whereas DCs cultured with medium alone did not induce significant CD8 + T cell expansion, CD40L-DCs induced a 1.4 to 2.8-fold expansion of CD8 + T cells after 6 d of coculture (Fig. 1 A). TSLP-DCs induced a 2.8 to 5.6-fold increase in CD8 + T cell number, which was 2 times more than that induced by CD40L-DCs (Fig. 1 A). Immunological Unresponsiveness Characterized by Increased Jun 01, 2004 · For example, bone marrow- derived cells induce deletional T cell tolerance in mice eing ovalbumin in the pancreas Adler et al. 1998, Kurts et al. 1997. Direct targeting of antigen to steady state DCs showed that DCs induce peripheral deletion of antigen-specific CD4 and CD8 T cells Bonifaz et al. 2002, Hawiger et al. 2001.
Oct 29, 2019 · Dendritic cells (DCs) are key regulators of immune responses that operate at the interface between innate and adaptive immunity, and defects in DC functions contribute to the pathogenesis of a variety of disorders. For instance, cancer evolves in the context of limited DC activity, and some autoimmune diseases are initiated by DC-dependent antigen presentation. Platelet P-selectin initiates cross-presentation and Dendritic cells (DCs) are adept at cross-presentation and initiation of antigen-specific immunity. Clinically, however, DCs produced by in vitro differentiation of monocytes in the presence of exogenous cytokines have been met with limited success. We hypothesized that DCs produced in a physiological manner may be more effective and found that platelets activate a cross-presentation program in
Jan 01, 2005 · Human dendritic cells (DCs) matured by glycoprotein 96 (Gp96) preferentially induce activation of allogeneic CD8 T cells. Monocyte-derived human dendritic cells were incubated with Gp96 or lipopolysaccharides at the indicated concentrations for 3 days and then cocultured with allogeneic peripheral blood lymphocyte.